Fig. 5.

E4orf4 inhibits JNK-induced cell death. (A–C) Flies expressing GFP, Eiger, or HepCA together with GFP or E4orf4 under GMR regulation were reared at 18 °C (A), 24 °C (B), or 29 °C (C), and the percent of adult eclosion was calculated for each group. n > 400, error bars represent SEs. All nonsignificant changes (P > 0.05) are marked as NS. *P < 0.001, **P < 0.05. (E–H and J–M) Representative male eyes with the indicated genotypes, reared at 18 °C, expressing GFP (E–H) or E4orf4 (J–M). Two different fly strains containing HepCA [hepCA(1) and hepCA(2)] were used. (D and I) Eye sizes of each genotype shown in E–H and J–M were normalized to control GMR>GFP,GFP eye sizes, and the average normalized value is shown in the graph. n > 30, except for male UAS-HepCA(1): n = 6. *P < 0.001 for all pairs. Error bars represent SEs. D, female eyes; I, male eyes.