Fig. 1.

Clinical features, pedigree, and histology of hair follicles in a Mexican family with X-linked CGH, deafness, and palate and dental anomalies. (A–D) Clinical photos of affected males with excessive hair growth on the back, shoulders, arms (A and B), chest (C), and (D) face. (D) Dental anomalies and a bulbous nose are also evident on patients. (E) Moderate hair growth is observed on the back of a female carrier. (Inset) A close-up image of a cowlick on the back of another carrier. (F) Pedigree of a four-generation family, three of whom are obligate carriers and eight of whom are affected. (G–J) Histology of a normal hair follicle and affected hair follicle, both from males, revealed that the hairs are of the terminal type, as they are medullated and highly pigmented. Affected hair follicles have a widened dermal papilla (white arrows), matrix (Mx), and hair shaft (HS) compared to control hair follicles. (Scale bars, 100 μm.)