Skip to main content
. 2013 Apr 15;110(19):7952–7957. doi: 10.1073/pnas.1221396110

Table 1.

Estimates of the parameters used in our dynamic HIV-FGS model

Variable Meaning Mean (95% CI) BGR diagnostic upper CI limit*
Inline graphic Probability of acquiring FGS, given childhood infection 0.457 (0.335–0.708) 1.193
Inline graphic Duration of HIV/AIDS infection 8.533 (7.725–9.106) 1.077
Inline graphic Intrinsic HIV transmission rate 0.317 (0.285–0.355) 1.079
Inline graphic Relative increase HIV transmission from men 1.112 (1.004–1.388) 1.025
Inline graphic Reduction rate of HIV transmission 5.096 (3.316–7.093) 1.131
Inline graphic Scale of influence of deaths on HIV transmission 1.413 (1.172–1.648) 1.105
Inline graphic Probability of acquiring FGS as a result of adulthood infection 0.017 (0.006–0.027) 1.183
Inline graphic Enhance HIV transmission in FGS-infected women 1.758 (1.142–2.404) 1.130

These parameter estimates produced the best fit of our dynamic model to epidemiological data for HIV and FGS prevalence and coinfection among rural Zimbabwean women (2, 6). The dynamic model was fit to these data using a Bayesian MCMC method to allow calculation of distributions for possible values for each of these parameters. The means of these distributions and their associated 95% credible intervals (CIs) are shown.

*

Brooks–Gelman–Rubin (BGR) method monitors convergence of iterative simulations. If the upper limit of the credible interval of the BGR diagnostic statistic for a given parameter is <1.2, that parameter is considered to have converged to a robust solution (35).