Table 1. Results and statistical analyses of life span assays.
Strain | Treatment | Max Life Span in Days ± SD | Mean Life Span in Days ± SD | n | p-Value versus Control | |
---|---|---|---|---|---|---|
N2 | 0.1 % DMSO control | 28.1 ± 1.5 | 21.6 ± 1.2 | 11 | ||
clofibrate 0.1 μM | 25.9 | 22.0 | 1 | n. s. | 0.8248 | |
clofibrate 1 μM | 27.2 | 22.6 | 1 | n. s. | 0.1877 | |
clofibrate 10 μM | 33.8 | 25.1 | 1 | *** | < 0.0001 | |
clofibrate 10 μM | 34.2 ± 0.9 | 23.0 ± 0.5 | 3 | *** | < 0.0001 | |
bezafibrate 0.1 μM | 32.0 | 23.3 | 1 | * | 0.0138 | |
bezafibrate 1 μM | 33.1 | 22.8 | 1 | * | 0.0137 | |
bezafibrate 10 μM | 34.4 | 22.9 | 1 | ** | 0.0078 | |
bezafibrate 10 μM | 32.5 ± 1.8 | 24.4 ± 0.7 | 3 | *** | 0.0002 | |
fenofibrate 0.1 μM | 34.6 | 22.5 | 1 | * | 0.0143 | |
fenofibrate 1 μM | 28.8 | 22.3 | 1 | n. s. | 0.1824 | |
fenofibrate 10 μM | 32.8 | 25.6 | 1 | *** | < 0.0001 | |
fenofibrate 10 μM | 30.2 ± 0.3 | 23.7 ± 1.1 | 3 | * | 0.0218 | |
nhr-49 | ||||||
ok2165 | 0.1 % DMSO control | 17.2 ± 1.2 | 12.2 ± 0.4 | 3 | ||
bezafibrate 10 μM | 17.7 ± 0.8 | 11.5 ± 0.2 | 3 | n. s. | 0.1606 | |
clofibrate 10 μM | 15.7 ± 0.4 | 11.0 ± 0.2 | 3 | neg. s. | < 0.0001 | |
fenofibrate 10 μM | 13.5 ± 0.2 | 9.5 ± 0.0 | 3 | neg. s. | < 0.0001 | |
gk405 | 0.1 % DMSO control | 16.7 ± 3.6 | 11.0 ± 0.4 | 3 | ||
bezafibrate 10 μM | 17.7 ± 3.7 | 11.4 ± 0.8 | 3 | n. s. | 0.0679 | |
clofibrate 10 μM | 17.5 ± 3.4 | 11.0 ± 0.3 | 3 | n. s. | 0.8962 | |
fenofibrate 10 μM | 14.5 ± 1.6 | 10.8 ± 0.2 | 3 | n. s. | 0.3035 |