Figure 1. Increased expression of Sir2 in the fat body extended lifespan of male and female flies.

Mated female (A) or male (C) UAS-Sir2>S₁106-Gal4 flies were fed 400 μM RU486 or diluent (ethanol) throughout adult life and lifespan was determined. As a control for a potential lifespan extending effect of RU486, the driver line was crossed to w¹¹¹⁸ and female (B) or male control flies (D) of the F1 generation were treated as the experimental flies. For p-values of log rank test see Table 1, n = 100 for each group.