Figure 4. Fat body Sir2 increases starvation survival in males.
Mated female (A) or male (B) UAS-Sir2>S1106-Gal4 flies fed on 1 % agar containing 400 μM RU486 or diluent (ethanol) and dead flies were scored 1-3 times a day. (C) Median lifespan of females was 217 ± 6 h and 215 ± 1 h in control and experimental flies, respectively. For males median lifespans were 172 ± 4 h and 185 ± 7 h for control and Sir2 overexpressing flies, respectively. Data are represented as means + SEM. Log rank analysis was performed using GraphPad Prism 6.00, n = 50.