Table 3.

Current ACOG and ACMG Guidelines

Who Should Be Offered Screening?
Any patient with a personal or family history of …	• Fragile X or fragile X-related disorders
	• Unexplained mental retardation or developmental delay
	• Autism
	• Ovarian insufficiency or elevated FSH at age < 40 years of unknown cause
Men with…	• Isolated cerebellar ataxia with tremor
	• Isolated cognitive impairment
Any woman who requests fragile X carrier screening regardless of history

ACMG, American College of Medical Genetics; ACOG, American Congress of Obstetricians and Gynecologists;

FSH, follicle-stimulating hormone