Table 3.
Glucocorticoid and Mineralocorticoid Treatment
| Mutation Group |
Significance of Mutation Group (ANOVA) | Significance of Tukey's Paired Comparisons |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Null | A | B | C | Null vs A | Null vs B | Null vs C | A vs B | A vs C | B vs C | ||
| Hydrocortisone only | |||||||||||
| n (%) | 10 (29.4%) | 10 (23.8%) | 9 (25.0%) | 7 (20.6%) | .864 | ||||||
| Median dose (range), mg/d | 30 (15–30) | 25 (15–30) | 30 (20–33) | 20 (10–35) | .021a | .178 | 1.000 | .023a | 1.000 | 1.000 | .343 |
| Median dose per BSA (range), mg/m2 · d | 17.3 (8.1–30.8) | 14.3 (7.9–16.8) | 15.7 (10.7–20.3) | 11.1 (4.5–20.8) | .043a | .321 | 1.000 | .053 | 1.000 | 1.000 | .375 |
| Prednisolone only | |||||||||||
| n (%) | 12 (35.3%) | 15 (35.7%) | 16 (44.4%) | 17 (50.0%) | .529 | ||||||
| Median dose (range), mg/d | 6.8 (5–9) | 7.5 (4–10) | 5.5 (3–10) | 5 (1–8) | .124 | ||||||
| Median dose per BSA (range), mg/m2 · d | 3.7 (2.6–4.9) | 3.5 (1.9–6.0) | 3.2 (1.2–4.9) | 3.0 (0.4–4.5) | .324 | ||||||
| Dexamethasone only | |||||||||||
| n (%) | 6 (17.6%) | 11 (26.2%) | 10 (27.8%) | 6 (17.6%) | .629 | ||||||
| Median dose (range), mg/d | 0.50 (0.25–0.75) | 0.50 (0.25–0.75) | 0.35 (0.25–0.75) | 0.25 (0.25–0.50) | .176 | ||||||
| Median dose per BSA (range), mg/m2 · d | 0.30 (0.13–0.49) | 0.24 (0.11–0.47) | 0.21 (0.13–0.46) | 0.14 (0.11–0.25) | .246 | ||||||
| Combination of glucocorticoids, n (%) | 6 (17.6%) | 6 (14.3%) | 1 (2.8%) | 3 (8.8%) | .171 | ||||||
| Reverse circadian glucocorticoid administration, n (%) | 17 (50.0%) | 19 (45.2%) | 17 (47.2%) | 14 (41.2%) | .914 | ||||||
| Fludrocortisone | |||||||||||
| n (%) | 32 (94.1%) | 33 (78.6%) | 14 (38.9%) | 10 (29.4%) | <.001a | .098 | <.001b | <.001b | <.001b | <.001b | .457 |
| Median dose (range), μg/d | 163 (100–500) | 100 (50–200) | 100 (50–200) | 100 (50–500) | .015a | .134 | .044a | .155 | 1.000 | 1.000 | 1.000 |
| Median dose per BSA (range), μg/m2 · d | 94 (51–231) | 64 (27–134) | 63 (30–121) | 57 (27–219) | .016a | .058 | .270 | .074 | 1.000 | 1.000 | 1.000 |
a
Significant at the 5% level.
b
Significant at the Bonferroni-adjusted level of 1.67%.