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Effect of hormonal replacement with E2 and/or progesterone on CYP2E1 expression in humanized CYP2E1 mice. CYP2E1 mRNA and activity levels are expressed as means ± SE (n = 10). Comparisons took place with basal CYP2E1 mRNA or PNP activity levels in OV mice, respectively. **P < 0.01. CYP2E1 Western blot images contain 1 sample per treatment. Each lane in the capture represents CYP2E1 protein amount in the microsomes of 1 transgenic mouse.
