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Sulforaphane (SNF), an activator of NRF2-mediated cytoprotection, reduced BUN levels after glucose injections in heterozygous Aqp11sjds/+ mutant (sjds/+) compared with WT mice (6 mice per group). Mice received intraperitoneal injections of 3 mg/kg body wt glucose daily for 3 days with or without SNF (2 mg/kg ip). Blood urea nitrogen (BUN) was assessed after the last glucose injection. Values are shown as means ± SE. *P < 0.05; **P < 0.0005, ***P < 0.001.
