Fig. 13.

Phlorizin, an inhibitor of sodium-dependent glucose transport, reduced BUN levels after glucose injections in heterozygous Aqp11^sjds/+ mutants. Aqp11^+/+ (WT; black bars) and Aqp11^sjds/+ (JS/+; grey bars) mice received intraperitoneal injections of 3 g/kg body wt glucose with phlorizin subcuntaneous administration (0.4 g/kg body wt) daily for 24 days. BUN was assessed on days 0, 8, and 24 of phlorizin injection. Values are shown as means ± SE. *P < 0.05 vs. glucose-treated mice without phlorizin administration; **P < 0.05 vs. WT mice that received glucose with phlorizin (n = 6 per group).