Fig. 2.

Quantification of glomerular volume distribution in rat kidneys 6 wk after UNx or sham operation. Top: distribution of the volume under the different conditions. Glomerular basement membranes of these animals were labeled using CF in vivo. In total 6.6 mg/kg body wt was administered over three intravenous injections over a period of 3 h. After UNx compensatory renal growth is induced. Glomerular volume distribution is shifted towards larger volumes (N_glom, number of glomeruli; V_glom, mean glomerular volume). eNOS, endothelial nitric oxide synthase. Changes can easily be detected by MRI. [From the laboratory of Gretz and colleagues, unpublished observations.]