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Disruption of the molecular clock alters heart rate and QRS intervals. A: 24-h heart rate measured using telemetry implants. Each point represents the half-hour moving average. Note the preservation of circadian rhythmicity and reduction in heart rate for the iCSΔBmal1−/− mice. BPM, beats/min. B and C: average RR and QRS intervals measured from ECG telemetry traces. Note the reduction in heart rate and the trend for longer RR intervals in the iCSΔBmal1−/− mice. *P < 0.05.
