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. 2013 Jan 30;304(10):C954–C965. doi: 10.1152/ajpcell.00383.2012

Fig. 3.

Fig. 3.

Disruption of the molecular clock alters the diurnal changes in RR and RR variability and increases the incidence of sinoatrial node arrhythmias. A: percentage of beats with the corresponding RR intervals separated by day and night for iCSΔBmal1+/+ and the iCSΔBmal1−/− mice. B: percentage of beats with the corresponding RR intervals over 24 h separated for before (pre-iCSΔBmal1+/+) and after the administration of vehicle or before (pre- iCSΔBmal1−/−) and after disruption of the cardiomyocyte molecular clock. C: representative ECG traces recorded in the pre-iCSΔBmal1−/− and the iCSΔBmal1−/− mice. Mice normally experience isolated pauses, but the iCSΔBmal1−/− mice showed episodes of pauses consistent with sinoatrial node arrhythmias (n = 6 pre-iCSΔBmal1+/+, iCSΔBmal1+/+ and n = 5 pre- iCSΔBmal1−/−, iCSΔBmal1−/−; *P < 0.05).