1-EBIO |
Ca2+ Activated K+ Channels |
|
Cardiac and cardiac pacemaker-like cells |
(Müller et al., 2011) |
1m |
GSK3β |
WNT |
Primitive streak, mesoderm, definitive endoderm |
(Bone et al., 2011) |
5-Azacytidine/5-aza-2'-deoxycytidine |
DNMT's |
|
Cardiomyocyte |
(Wang et al., 2010; Xu et al., 2002; Yoon et al., 2006) |
ALK5-I/II Inhibitor + DAPT |
ALK5 +γ-secretase |
TGFβ+ NOTCH |
Pancreatic endocrine cells |
(Rezania et al., 2011) |
ATRA |
RARs/RXRs |
|
Mainly neurogenesis |
(Desbordes et al., 2008) |
BIO + SB431542 |
GSK3β+ ALK4,5 & 7 |
WNT + TGFβ |
Neural crest |
(Menendez et al., 2011) |
BMS-189453 + NOGGIN |
RARs/RXRs |
|
Cardiomyocytes |
(Zhang et al., 2011) |
CHIR99021 + DORSOMORPHIN + RA + SB431542 |
GSK3β+ ALK2, 3 and 6+ ALK4,5 & 7 |
WNT + TGFβ |
hiPSCs into definitive endoderm then pancreatic cells |
(Kunisada et al., 2011) |
CHIR99021 + SB431542 + Compound E |
GSK3β+ ALK4,5 & 7 +γ-secretase |
WNT + TGFβ+ NOTCH |
Cardiomyocytes |
(Kattman et al., 2011) |
Chlorate |
Downregulation of Sulfonation |
WNT, TGFβ, and FGF/ERK |
Mature neurons |
(Sasaki et al., 2010) |
Cobalt chloride |
HIF-1α stabilization |
|
Cardiomyocyte differentiation to functionally mature cardiomyocytes |
(Ng et al., 2011) |
Corticosteroids |
|
|
Trophoblast and mesodermal |
(Barbaric et al., 2010) |
CSA |
Calcineurin |
NFAT |
Cardiomyocyte differentiation from ESC-derived mesodermal cells in visceral endodermal stromal cell co-culture |
(Mummery et al., 2003) |
Decreased hypertrophy of ESC-derived cardiomyocytes |
(Lim et al., 2000) |
Cyclopamine |
SMO |
Hh |
Astrocytes |
(Lee et al., 2006) |
Cymarin |
RARs/RXRs |
|
Mesodermal/endodermal |
(Desbordes et al., 2008)
|
Dorsomorphin |
ALK2, 3 and 6 |
TGFβ |
Neurogenesis |
(Kim et al., 2010; Wada et al., 2009; Zhou et al., 2010) |
Dorsomorphin + SB431542 |
ALK2, 3 and 6 + ALK4,5 & 7 |
TGFβ |
Pancreatic Cells Neurogenesis |
(Nostro et al., 2011) |
(Kim et al., 2010; Morizane et al., 2011) |
IDE1 and 2 |
|
TGFβ |
Definitive endoderm |
(Borowiak et al., 2009) |
ILV + KAAD-Cyclopamine |
PKCs + SMO |
Hh |
Pancreatic Progenitors |
(Chen et al., 2009; D’Amour et al., 2006; Kroon et al., 2008; Thatava et al., 2011). |
IWP-4, IWR-1 |
|
WNT |
Cardiomyocytes |
(Hudson et al., 2011) |
IWR-1 |
|
WNT |
Cardiomyocytes |
(Ren et al., 2011) |
IWR-1, IWP-3 |
|
WNT |
Cardiomyocytes |
(Willems et al., 2011) |
LY294002 |
PI3K |
PI3K/AKT/mTOR |
Endodermal |
(Touboul et al., 2010) |
NaB |
Histone Proteins |
|
Hepatocytes differentiation Endodermal and trophectodermal |
(Hay et al., 2008) (Maimets et al., 2008) |
Nutlin |
TP53 |
|
Primitive endoderm and trophectoderm differentiation |
(Maimets et al., 2008) |
PD98059 |
MAP2K1/MEK1 |
MEK/ERK |
Haematopoietic and functional endothelial and smooth muscle cells |
(Park et al., 2010) |
Purmorphamine |
SMO |
Hh |
Ventral spinal progenitors and motor neurons |
(Li et al., 2008) |
RA |
|
|
Functional Insulin Producing Cells |
(Jiang et al., 2007) |
Rapamycin |
mTOR |
PI3K/AKT/mTOR |
Mesodermal and endodermal |
(Zhou et al., 2009) |
|
|
|
Osteogenesis |
(Lee et al., 2010) |
Red Ginseng |
|
|
Cardiac-progenitor like cells from hESC-derived EBs. |
(Kim et al., 2011) |
Rosiglitazone |
PPARγ |
|
Adipocytic Differentiation |
(Xiong et al., 2005) |
Sarmentogenin |
|
|
Mesodermal/Endodermal |
(Desbordes et al., 2008) |
SB203580 |
p38 MAPK |
MAPK |
Cardiomyogenesis |
(Gaur et al., 2010; Kempf et al., 2011) |
SB431542 |
ALK4,5 & 7 |
TGFβ |
Primitive NPCs |
(Li et al., 2011) |
|
|
|
Myocyte progenitors |
(Mahmood et al., 2010) |
|
|
|
hESC-derived hemogenic epithelial cells into HPCs |
(Wang et al., 2011) |
|
|
|
Cardiomyocytes |
(Graichen et al., 2008; Xu et al., 2008), |
|
|
|
Endothelial cells |
(James et al., 2010). |
|
|
|
hESC-derived endoderm cells into hepatic progenitors |
(Touboul et al., 2010) |
SB431542 + CKI-7 |
ALK4,5 & 7 + Casein Kinase |
TGFβ+ LEFTYA |
Retinal |
(Osakada et al., 2009) |
SB431542 + NOGGIN |
ALK4,5 & 7 + BMP |
TGFβ |
Neurogenesis |
(Chambers et al., 2009) |
|
|
|
Anterior Foregut Endoderm |
(Green et al., 2011) |
|
|
|
Endocrine differentiation from hESC-derived pancreatic progenitors |
(Nostro et al., 2011) |
SB431542 + Purmorphamine |
ALK4,5 & 7 + SHH |
TGFβ+ SHH |
Motor Neuron Precursors |
(Patani et al., 2009) |
SP60125 |
JNK/AP-1 |
Non-canonical WNT |
Haematopoiesis |
(Rai et al., 2011) |
Stauroprimide |
|
|
Primes for multilineage differentiation |
(Zhu et al., 2009) |
Synthetic RA Analogues |
RARs/RXRs |
|
Mainly Neurogenesis |
(Christie et al., 2008) |