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. 2013 Apr 25;169(2):337–352. doi: 10.1111/bph.12139

Figure 3.

Figure 3

Mechanisms involved in the anti-inflammatory activity of minocycline: inhibitory effects on enzyme activities, like iNOS, MMPs, COX-2 or PLA2; inhibition of apoptosis, through the inhibition of caspase-1 and caspase-3 activation and the enhancement of Bcl-2-derived effects; antioxidant properties and inhibition of immune cell activation and proliferation.