Figure 3.
Mechanisms involved in the anti-inflammatory activity of minocycline: inhibitory effects on enzyme activities, like iNOS, MMPs, COX-2 or PLA2; inhibition of apoptosis, through the inhibition of caspase-1 and caspase-3 activation and the enhancement of Bcl-2-derived effects; antioxidant properties and inhibition of immune cell activation and proliferation.