Figure 4. DG-restricted YFP-tomosyn1-expression alters swimming strategies performance during probe trials in the MWM test.
YFP-tomosyn1-overexpressing mice use swimming strategies of a lower cognitive ability than YFP-overexpressing mice under more stringent conditions (using medium-sized platform) during probe trials in the MWM test. (a) Examples for swimming strategies employed by mice during probe trials in the MWM. From left to right non-cognitive strategies (random swim, circling) are followed by strategies with cognitively higher spatial accuracy. (b) YFP-tomosyn1-overexpressing mice showed higher levels of random swim in P1 and P2 than (c) YFP-overexpressing mice, who displayed higher levels of scanning and focused searching.