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. Author manuscript; available in PMC: 2013 Nov 10.
Published in final edited form as: Nature. 2013 Apr 14;497(7448):254–257. doi: 10.1038/nature12048

Figure 3. Cas9, tracrRNA, and scaRNA facilitate evasion of TLR2 signaling by temporal repression of FTN_1103.

Figure 3

IL-6 secretion from wild-type (WT) and TLR2−/ − bone marrow-derived macrophages (BMDM) (A) unstimulated (Un) or stimulated with membrane proteins (relative MOI of 20:1 for 5 hours) from wild-type (WT), the indicated single mutants, or double deletion strains also lacking FTN_1103 (n = 3), or (B) infected with the same strains at an MOI of 20:1 for 5 hours (n =6). Relative expression of (C) FTN_1103, (D) cas9, (E) scaRNA, and (F) tracrRNA during infection of BMDM with the indicated strains (n = 3, bars represent s.d.).