Figure 5. Combination of PF02341066 and radiation inhibits tumor growth in lung cancer xenograft model.

H3122 lung cancer cells (1 ×106 cells in 100 µl PBS) were injected subcutaneously into athymic nude mice. After 6 to 8 days, mice were treated with vehicle control, PF02341066 (100 mg/kg twice a day for 7 consecutive days), radiotherapy, or combined PF02341066 and radiotherapy. Mice were irradiated 1 hour after PF02341066 treatment with 2 Gy daily for 5 consecutive days. Tumors were measured regularly and were graphed by the days.