Standard dosage	5 mg twice daily
	2.5 mg twice daily (if any two of the following: age ≥ 80 years, weight ≤ 60 kg, serum creatinine ≥ 1.5 mg/dL)
Contraindications	Absolute: Active bleeding, renal impairment (creatinine clearance < 15)
	Relative: Elevated bleeding risk, high-risk activities (extreme sports, certain occupations)
Main drug interactions	Antifungals, macrolides, rifampin, carbamazepine, phenytoin
Main side effects	Bleeding
Special points	Factor Xa inhibitor.
	Superior safety and efficacy compared with warfarin [32].
	No INR monitoring required.
	Limited interaction with medication and food.
	Can be administered with or without food.
	Patients need education regarding bleeding prevention.
	No effective method to rapidly reverse anticoagulation effect.
Cost/cost-effectiveness	Non-generic (approximate cost $250 per month). Periodic blood draws not required.