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. Author manuscript; available in PMC: 2014 May 6.
Published in final edited form as: Mol Pharm. 2013 Apr 16;10(5):2031–2044. doi: 10.1021/mp400054e

Table 1.

Pharmacokinetic parameters evaluated by non-compartmental analysis (NCA) and population analysis (POP) of blood data using Phoenix® WinNonlin® software.

NCA POP POP SE
SH-Gel NP SH-Gel PEG SH-Gel PEG
Peptide
SH-Gel NP SH-Gel PEG
± Peptide
SH-Gel NP SH-Gel PEG
± Peptide
AUCinf
(h*%ID/mL)
18.60 24.67 25.28 AUCinf
(h*%ID/mL)
20.74 1.95
CL (mL/h) 5.376 4.054 3.956 CL (mL/h) 4.822 0.454
MRT (h) 32.27 21.76 15.33 MRT (h) 31.19 19.47 8.03 4.90
Vss (mL) 173.5 88.2 60.6 Vss (mL) 150.4 93.9 28.3 17.1
Lambda_z
(1/h)
0.0224 0.0262 0.0332 Beta (1/h) 0.0198 0.0362 0.0042 0.0067
HL Lambda_z
(h)
31.01 26.46 20.89 HL Beta (h) 35.05 19.16 7.53 3.57
AUClast ± SE
(h*%ID/mL)
10.71
(±1.01)
17.38
(±1.32)
19.56
(±1.01)
Alpha (1/h) 1.577 1.428 0.156 0.145
HL Alpha (h) 0.4393 0.4852 0.0435 0.0494
A (%ID/mL) 0.1270 0.1251 0.0140 0.0140
B (%ID/mL) 0.002510 0.004333 0.000306 0.000516
V1 (mL) 7.724 0.835
V2 (mL) 142.7 86.1 28.1 17.0
Ke (1/h) 0.6242 0.0784
HL Ke (h) 1.110 0.139
K12 (1/h) 0.9231 0.1171
HL K12 (h) 0.7508 0.0952
K21 (1/h) 0.04997 0.08276 0.00803 0.01331
HL K21 (h) 13.87 8.37 2.23 1.35

AUC = Area under the concentration versus time curve. AUCinf = AUC until infinity. CL = Total body clearance. MRT = Mean Residence Time. Vss = Steady State Volume of distribution. Lambda_z = Slope of the log-linear terminal phase (NCA). HL = Half life. AUClast = AUC until last measurement time point. Beta = Slope of the log-linear terminal phase (POP). Alpha = Slope of the residual log-linear phase. A = Intercept of the residual log-linear phase. B = Intercept of the log-linear terminal phase. V1 = Volume of the central compartment. V2 = Volume of the peripheral compartment. Ke = Elimination rate constant from central compartment. K12 = Transfer rate constant from central compartment to peripheral compartment. K21 = Transfer rate constant from peripheral compartment to central compartment.