Table 3.

HIF1α binding motifs identified in the promoters of genes relevant for mast cell function. −2000/+100 sequences were scanned for Putative HIF1α binding sites for each gene. Locations of putative binding sites are relative to the ATG initiation codon

Class	Gene symbol	Number of HRE	Matrix similarity	Sequence	Strand
Preformed mediators	CMA1	1	0.894	−124gaagaaaaCGTGaccat−108	(+)
	CPA3	2	0.974	−1763catggaCGTGttttt−1749	(+)
			0.698	−603ttcacCACGttggccag−587	(−)
	CTSG	0
	TPSAB1	3	0.973	−776gggtctcaCGTGttggccag−760	(+)
			0.946	−731cccaccccCGTGgattc−715	(+)
			0.976	−368cgggggcaCGTGttaca−352	(+)
	TPSB2	2	0.946	−732gccaccccCGTGgattc−716	(+)
			0.976	−368gggggCGTGttaca−716	(+)
	TPSG1	5	0.982	−1678tcaggaCGTGgcagg−1664	(+)
			1.000	−1598cacccaCGTGgctg−1585	(+)
			0.980	−839ctccccaCGTGctggc−823	(+)
			0.976	−816gcggcCACGtctgtgcc−800	(−)
			0.989	−515ctgccggaCGTGgggac−499	(+)
Cytokines	INFG	0
	IL1A	1	0.931	−786gtagcCACGTagccacg−770	(−)
	IL1B	1	0.948	−857tcttctaaCGTGggaaa−841	(+)
	IL4	0
	IL5	2	0.945	−1502accaaaCGTGgtaca−1488	(+)
			0.955	+40gctgcctaCGTGtatgc+56	(+)
	IL6	0
	IL8	0
	IL13	2	0.975	−1998cggCAAGTgcgcgc−1985	(−)
			0.945	−809gccagacaCGTGcacac−793	(+)
	IL16	1	0.973	−1725gagCACGTagaccc−1712	(−)
	IL18	1	0.892	−1600gggcaaCGTGgtgaa−1586	(+)
	TGFB1	2	0.989	−1855gccccaCGTGgcggc−1841	(+)
			0.871	−1645ctccaACGTcaccac−1631	(+)
	TNF	1	0.975	+19atccgggaCGTGgagct+35	(+)
Chemokines	CCL2	0
	CCL3	1	0.955	+65ctgcatCACGtgagtct+81	(+)
	CCL5	1	0.973	−41agacagcaCGTGgacct−25	(+)
Growth	CSF2	1	0.986	−1141tgggcaCGTGtgggc−1127	(+)
factors	VEGFA	2	0.987	−1552tgaggaCGTGtgtgt−1538	(+)
			0.892	−1353tccgaACGTaacctc−1339	(+)
Receptors	FCER1A	0
	FCER1G	0
	KIT	4	0.916	−814ggggaaaaCGTGtatga−798	(+)
			0.979	−496cgcccgaaCGTGctcga−480	(+)
			0.916	−424tgccctaaCGTGtgcgt−408	(+)
			0.897	−45agctggaaCGTGgacca−29	(+)
	MS4A2	0