Table 3.

Percentage of children with predicted maintenance doses underestimated (prediction <80 % of actual dose), ideal (prediction ± 20 % of actual dose) or overestimated (prediction >120 % of actual dose), and bias and imprecision for the different dose prediction models

	Dose Underestimated	Dose Ideal	Dose Overestimated	Bias (Mean Prediction Error)	Imprecision (Root Mean Square Error)
A priori dose predictions
Fixed dose 0.2 mg/kg	8 %	33 %	59 %	1.94	2.19
Algorithm by Nowak-Göttl et al. [12]	28 %	35 %	37 %	−0.26	1.05
Algorithm by Moreau et al. [13]	16 %	33 %	51 %	0.32	0.98
Algorithm by Biss et al. [14]	31 %	41 %	28 %	−0.03	0.90
Bridged KPD model	35 %	41 %	24 %	−0.13	0.94
A posteriori dose prediction
Bridged KPD model	14 %	70 %	16 %	−0.04	0.57