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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Diabetologia. 2012 Oct 3;56(1):126–135. doi: 10.1007/s00125-012-2732-9

Fig. 3.

Fig. 3

IL-12 neutralising antibody inhibits human islet gene expression induced by pro-inflammatory cytokines. (a) Induction of IFNγ expression in human islets stimulated by IL-12 for 4 h in the presence (triangles) or absence (squares) of a neutralising antibody to IL-12. (b) Pro-inflammatory cytokine or IL-12 induced an increase in IFNγ expression in the absence or presence of a neutralising antibody to IL-12. (c) Pro-inflammatory cytokines or IL-12 induced an increase in IFNγ expression after stimulation for 4 and 24 h. The graphs are representative of three (a), six (b) or five (c) experiments in separate donors. *p<0.05, **p<0.01, ***p<0.001. IL-12Ab, antibody to IL-12