Table 1.
Heart and body weights in normoxic and CH WT and young and older SOD1 KO mice
| Genotype | Exposure | BW, g | RV, g | LV+S, g | TV/BW, g/kg | n = mice |
|---|---|---|---|---|---|---|
| SOD1 WT | Normoxia | 28.4 ± 2.0 | 0.028 ± 0.001 | 0.092 ± 0.004 | 3.29 ± 0.08 | 13 |
| SOD1 WT | CH | 26.7 ± 1.3 | 0.034 ± 0.003* | 0.094 ± 0.005 | 4.85 ± 0.23* | 6 |
| SOD1 KO | Normoxia | 26.6 ± 2.0 | 0.026 ± 0.001 | 0.082 ± 0.004 | 3.09 ± 0.09 | 14 |
| SOD1 KO | CH | 26.7 ± 1.8 | 0.033 ± 0.004* | 0.081 ± 0.0.07# | 4.27 ± 0.18*† | 6 |
| SOD1 WT 5 mo | Normoxia | 30.6 ± 2.9 | 0.92 ± 0.05 | 2.67 ± 0.08 | 3.59 ± 0.13 | 5 |
| SOD1 KO 5 mo | Normoxia | 28.1 ± 0.8 | 0.92 ± 0.01 | 2.61 ± 0.04 | 3.54 ± 0.05 | 7 |
Values are means ± SE. In the bottom 2 rows, right ventricle (RV) and left ventricle + septum weight (LV+S) values are per body weight (BW) and are in g/kg.
CH, chronic hypoxia; WT, wild-type; SOD1, superoxide dismutase 1; KO, knockout; TV, total ventricular weight.
*
P < 0.05 vs. normoxia.
†
P < 0.05 vs. WT.