Fig. 4.
Effect of pyruvate on ICa,L response to okadaic acid (OA). Myocytes from sham-operated and MI hearts were dialyzed with 1 μmol/l OA with or without pyruvate pretreatment. A and B: mean current-voltage relations of ICa,L in sham-operated (A) and MI (B) myocytes with (black symbols) or without (white symbols) OA stimulation. C: maximum ΔICa,L in response to 1 μmol/l OA in myocytes untreated or pretreated with 5 mmol/l pyruvate for 5–8 h. *P < 0.05 compared with sham + OA; #P < 0.05 compared with untreated MI + OA. Numbers in parentheses indicate number of myocytes in each group.