Table 4.
Pathways downregulated at 3 m in PI
| KEGG Pathway | Related Genes |
|---|---|
| Pentose and glucuronate interconversions; fatty acid uptake | Ugt2b34, Akr1b8, Galk2; Fabp7 |
| Wnt signaling pathway | Wnt inhibitors: Dkk1, Axin2; Gbp3, Tcfap2a |
| Cell adhesion | Cadm1, Col2a1, Actb, Glg1 |
| Cell cycle and division | E2f4, Brca2, Mnd1, Plk5, Smc4, Vps24, Gadd45b, Krtap16-7 |
| MAPK signaling pathway | Gad45b, Nfκb1, Ppp5c, Hsp8, Spry4, Mdfi, Map3k15, Rab10/5c |
| Ubiquitin-mediated proteolysis, lysosomal function | Fbxo2, Ube2 s, Ube3a, Uckl1, Trim68, Proz, Klk1b16, Tmprss4, Tnfaip8, Ctso, Lamp3, Dnajb8 |
| Calcium signaling pathway | CamK2, Cacna2d1, Atp2b2, Mid1, Spsb2, |
| DNA damage and repair | Ogg1, Brca2, Rrm2b, Tdg |
| Regulation of transcription-DNA dependent, RNA metabolic processes | Nfκb1, Cebpd, E2f4, Evx2, Mdfi, Sox15/16, Creb3l3, forkhead box genes, Zinc finger proteins |
| Ion channel activity | Atp2b2, Atp7b, Rab10, Cacnad2, Fabp7, Kcnk7/2, Kcnh4 |
| GPCR protein signaling pathway; neuroactive ligand-receptors | Agtr1a, Agtrap, Npffr2, Grin2d, Mtnr1b, Mpffr2, P2x, Syn1 |
| Natural killer cell-mediated cytotoxicity | Shc2, Ifna9, killer cell lectin-like receptors, Pik3d |
These included ubiquitin-mediated proteolysis, Ca2+ signaling, transcription, and GPCR signaling. Genes representing hubs are in bold, and the most downregulated genes are underlined.