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Reactive hyperemia is attenuated in the presence of glibenclamide. A: group data present baseline flow and the hyperemic response following a 15-s total occlusion of coronary flow. Responses were significantly reduced in hearts with KATP channel blockade by glibenclamide (10 μM, n = 5). B: repayment of flow debt was reduced by 54.4% in WT mice treated with glibenclamide (*P < 0.05 vs. WT by unpaired t-test) (n = 5).
