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Adenosine-induced KATP current is reduced in smooth muscle cells lacking the adenosine A2A receptor. Representative traces show that adenosine (10 μM) activated glibenclamide-sensitive KATP current in smooth muscle cells from WT (A) and A2B KO (C) mice, but not A2A KO (B) or A2A/A2B (D) DKO mice. For group data (E), KATP conductance (nS/pF) was normalized to control for cells from n = 4–5 mice in each group. *P < 0.05 vs. WT by one-way ANOVA.
