Fig. 6.
Catalase (Cat)-sensitive portion of reactive hyperemia is absent in hearts lacking the adenosine A2A receptor. A: group data show baseline flow and hyperemic responses in hearts from WT and A2A KO mice in the absence or presence of catalase (1,250 U/ml). Hyperemic responses were reduced by catalase in hearts from WT (n = 7) but not A2A KO (n = 6) mice. Catalase reduced the repayment of flow debt 30% in hearts from WT (B) mice (*P < 0.05 by unpaired t-test), but had no effect in hearts from A2A KO mice (C).