Table A1.

Initial conditions for state variables in mathematical model of human atrial AP^*

State Variable	Definition	WT	Ankyrin-B+/−
m	Fast Na+ current (INa) activation gate	0.004147463955	0.00318851486
h	INa inactivation gate	0.9421032891	0.9598653389
j	INa slow inactivation gate	0.9319148046	0.9688717543
d	L-type Ca2+ current (ICa) activation gate	1.793553646e-04	0.0001466632492
f	ICa voltage-dependent inactivation gate	0.8466729054	0.8891946221
fca	ICa calcium-dependent inactivation gate	0.5727907784	0.5594239293
Xr	Rapidly activating K+ current activation gate	0.02303434883	0.01534625493
Xs	Slowly activating K+ current activation gate	0.03616188931	0.03017466983
Oa	Transient outward K+ current (Ito) activation gate	0.03436021906	0.03141789388
Oi	Ito inactivation gate	0.9987671846	0.9991357877
ua	Ultrarapid K+ current (IKur) activation gate	0.006237057018	0.00527170832
ui	IKur inactivation gate	0.9891443725	0.9897469285
U	Ryanodine receptor (RyR) Ca2+-dependent activation gate	4.537711703e-16	2.174552101e-16
v	RyR Ca2+-dependent inactivation gate	1.0	1.0
W	RyR voltage-dependent inactivation gate	0.9990895327	0.9991716587
[Ca2+]i, mM	Ca2+ concentration in myoplasm	0.0002599348619	0.0002745599852
[Ca2+]Rel, mM	[Ca2+] in sarcoplasmic reticulum release compartment	0.4298392427	0.521326844
[Ca2+]Up, mM	[Ca2+] in sarcoplasmic reticulum uptake compartment	1.960512954	2.041848657
[Ca2+]cmdn, mM	Ca2+-bound calmodulin	0.004923177073	0.005171523579
[Ca2+]trpn, mM	Ca2+-bound troponin	0.0239435873	0.02481321084
[Ca2+]csqn, mM	Ca2+-bound calsequestrin	3.495084787	3.945479851
[Na+]i, mM	Na+ concentration in myoplasm	15.19468146	16.43681531
[K+]i, mM	K+ concentration in myoplasm	134.9547735	133.6894531
Vm, mV	Transmembrane potential	−79.01495665	−80.62135663

^*Single cell was paced to steady state at cycle length (CL) = 300 ms. AP, action potential; WT, wild-type.