Table A4.

Initial conditions for state variables in mathematical model of mouse atrial AP^*

State Variable	Definition	WT	Ankyrin-B+/−
M	Fast INa activation gate	0.00135132373	0.001504400009
H	INa inactivation gate	0.9873598055	0.9854360416
J	INa slow inactivation gate	0.9918930493	0.9908065458
D	ICa activation gate	0.0009336318521	0.001011615048
F	ICa voltage-dependent inactivation gate	0.971452238	0.9965778666
fca	ICa calcium-dependent inactivation gate	0.6432093256	0.8230278873
Xr	Rapidly activating K+ current activation gate	0.004254403903	6.234082795e-05
Xs	Slowly activating K+ current activation gate	0.01764536694	0.01599482291
Oa	Transient outward K+ current (Ito) activation gate	0.001906509835	0.002030472113
Oi	Ito inactivation gate	0.9999848553	0.9999849009
ua	Ultrarapid K+ current (IKur) activation gate	0.01217305509	0.0003118014711
ui	IKur inactivation gate	0.9667493143	0.9927894458
aKss	Noninactivating steady-state K+ current (IKss) activation gate	0.8135516746	0.7868359662
U	Ryanodine receptor (RyR) Ca2+-dependent activation gate	8.021780287e-32	0
V	RyR Ca2+-dependent inactivation gate	1.0	1.0
W	RyR voltage-dependent inactivation gate	0.9993892777	0.9993657578
[Ca2+]i, mM	Ca2+ concentration in myoplasm	0.0001938318203	7.524196035e-05
[Ca2+]Rel, mM	[Ca2+] in sarcoplasmic reticulum release compartment	1.006559386	1.481621283
[Ca2+]Up, mM	[Ca2+] in sarcoplasmic reticulum uptake compartment	3.945619176	1.916274235
[Ca2+]cmdn, mM	Ca2+-bound calmodulin	0.00376544676	0.001532272634
[Ca2+]trpn, mM	Ca2+-bound troponin	0.01955555503	0.009156042428
[Ca2+]csqn, mM	Ca2+-bound calsequestrin	5.571692766	6.493721346
[Na+]i, mM	Na+ concentration in myoplasm	20.28987641	13.367893
[K+]i, mM	K+ concentration in myoplasm	129.5105865	136.7678717
Vm, mV	Transmembrane potential	−85.80492414	−85.16157828

^*Single cell was paced to steady state at CL = 300 ms.