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Total histopathology score.
| NVC | LVT | HVT | |||
|---|---|---|---|---|---|
| 5 h | 12 h | 5 h | 12 h | ||
| Score | 1.0 (0.0 to 2.0) | 1.5 (1.0 to 2.8) | 1.0 (0.0 to 2.5) | 3.0 (2.0 to 3.8) | 4.0 (3.0 to 4.8)∗∗, # |
NVC = nonventilated control; LVT, HVT = ventilation with LVT/PEEP or HVT/ZEEP settings; 5 h, 12 h = 5 or 12 hours of ventilation. Data are presented as median (IQR) of 6–8 mice per group. *illustrates primary statistical analysis (**P < 0.01 versus NVC); #illustrates secondary statistical analysis (# P < 0.05 versus 12 h LVT).
