Table 4.
Frequency and mean morphometric values (±S.D.) for hepatotoxicity indicators in control mice (0.0 mg/g, N=4) and mice administered 0.125 mg/g (N=8), 0.5 mg/g (N=7), and 1.0 mg/g (N=6) of muricid extract (ME). Significant differences between control and treated mice are indicated by * (Tukey, P < 0.05; Mann-Whitney, P < 0.017. Abbreviations: FOV: field of view; IF: inflammatory foci.
| ME dose (mg/g) |
Hepatocyte density (cells/mm2) | Hepatocyte diameter (µm) |
Sinusoid diameter (µm) |
IF frequency (foci/20 FOV) |
|---|---|---|---|---|
| 0.000 | 23.73 ± 4.31 | 18.98 ± 3.20 | 4.47 ± 1.07 | 0.15 ± 0.42 |
| 0.125 | 30.16 ± 5.51* | 15.16 ± 2.43* | 5.93 ± 2.09* | 0.55 ± 0.90* |
| 0.500 | 27.68 ± 5.95* | 16.46 ± 2.65* | 5.91 ± 1.57* | 0.73 ± 1.11* |
| 1.000 | 24.80 ± 4.98 | 17.29 ± 2.88* | 5.43 ± 1.36* | 0.76 ± 0.07* |