Fig. 3.

Intravesical instillation of saline did not affect peripheral mechanical sensitivity. The mechanical sensitivity threshold was reduced 3 h after instillation of acrolein. Treatment with GP1a attenuated increased mechanical sensitivity, and the effect of GP1a was reversed by the selective CB2 antagonist AM630. Baseline (open bar) and 3 h after treatment with saline or acrolein (gray bar). n = 6 (saline-treated controls). n = 8 (other treatment groups). *P < 0.01 vs. saline-treated. #P < 0.05 vs. acrolein-treated. @P < 0.05 vs. acrolein+GP1a-treated.