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Treatment with U0126 (30 mg/kg), an inhibitor of ERK1/2 phosphorylation, attenuated the increase of bladder weight (A) and the reduction in mechanical sensitivity threshold-induced by acrolein (B). n = 6. *P < 0.05, **P < 0.01 vs. saline-treated, respectively. #P < 0.05 vs. acrolein-treated.
