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Heme modulates cytokine secretion in AM. Rat AMs (1 × 106/mL) were treated with different concentrations of heme (3–30 μM) for 3 h. The culture supernatants were subsequently collected and analyzed for IL-1β, IL-6, IL-10, TNF-α, and CINC-1 secretion by ELISA. The data shown are representative of three independent experiments. The mean ± S.D. is presented. *P < 0.05 when compared with untreated cells; # P < 0.05 when compared to heme 3 and 10 μM.
