Table 4.
BIOCART terms distribution of downregulated genes (upexpression level of miRNAs) of TCM syndromes in CHB.
| Syndromes | Biocart term | Genes |
|---|---|---|
| LGDHS/normal | Hypoxia-inducible factor in the cardiovascular system | EP300, VHL, CREB1, VEGFA, ASPH |
| LDSDS/normal | Control of gene expression by vitamin D receptor | COPS2, BAZ1B, SMARCC1, SMARCD1, CHAF1A, SMARCA4 |
| LKYDS/normal | Melanocyte development and pigmentation pathway | CREB1, BCL2, MITF, KITLG, KIT |
| LGDHS/LDSDS | Cell cycle: G1/S checkpoint | E2F1, SMAD4, SKP2, CDK6, RB1, CDK4, ATM, CDC25A, CCND1, CDKN1A, CDKN1B, DHFR, CDKN2A, HDAC1, CDKN2B |
| p53 signaling pathway | E2F1, CDKN1A, CCND1, BCL2, PCNA, APAF1, RB1, CDK4, TIMP3, GADD45A, ATM | |
| Cyclin, cell cycle regulation | E2F1, CCNB1, CDKN1A, CCND1, CDKN1B, CDKN2A, CDKN2B, CDK6, RB1, CDK4, CDC25A | |
| Cell cycle: G2/M checkpoint | CCNB1, CDKN1A, YWHAH, EP300, CHEK1, MYT1, GADD45A, ATM, BRCA1, WEE1 | |
| LDSDS/LKYDS | Role of BRCA1, BRCA2, and ATR in cancer susceptibility | RAD1, NBN, BRCA2, BRCA1, RAD51 |
| Cyclin, cell cycle regulation | CCNE1, CDKN2A, CDKN2D, RB1, CDC25A |