Table 3.

Weighted diagnostic performance of 1,5-anhydroglucitol, fructosamine, and glycated albumin to identify cases of diabetes comparing four definitions of diabetes

	Total study population (N= 1,719)	Excluding persons taking diabetes medications (N=1,421)	Excluding persons with a history of diabetes* (N = 1376)
	AUC (95% CI)**	AUC (95% CI)**	AUC (95% CI)**
Diabetes defined by hemoglobin A1c ≥ 6.5% (N = 252)
1,5-Anhydroglucitol	0.74 (0.69 to 0.78)	0.66 (0.58 to 0.74)	0.65 (0.56 to 0.73)
Fructosamine	0.83 (0.79 to 0.87)	0.71 (0.63 to 0.78)	0.69 (0.61 to 0.77)
Glycated Albumin	0.87 (0.83 to 0.90)	0.73 (0.64 to 0.81)	0.71 (0.62 to 0.78)
Fasting Glucose	0.83 (0.79 to 0.87)	0.76 (0.69 to 0.83)	0.74 (0.66 to 0.81)
Diabetes defined by fasting glucose ≥ 126 mg/dL (≥6.99 mmol/L) (N = 297)
1,5-Anhydroglucitol	0.70 (0.65 to 0.75)	0.60 (0.53 to 0.67)	0.59 (0.51 to 0.66)
Fructosamine	0.83 (0.79 to 0.87)	0.78 (0.72 to 0.83)	0.77 (0.71 to 0.83)
Glycated Albumin	0.86 (0.82 to 0.89)	0.80 (0.74 to 0.85)	0.80 (0.74 to 0.85)
Hemoglobin A1c	0.87 (0.85 to 0.90)	0.82 (0.76 to 0.86)	0.81 (0.75 to 0.86)
Diabetes defined by history of diabetes* (N = 343)
1,5-Anhydroglucitol	0.69 (0.65 to 0.74)	0.60 (0.54 to 0.67)	-
Fructosamine	0.81 (0.77 to 0.85)	0.74 (0.66 to 0.82)	-
Glycated Albumin	0.85 (0.81 to 0.88)	0.74 (0.66 to 0.83)	-
Hemoglobin A1c	0.87 (0.84 to 0.89)	0.73 (0.64 to 0.82)	-
Fasting Glucose	0.80 (0.76 to 0.84)	0.73 (0.64 to 0.82)	-
Diabetes defined by hemoglobin A1c ≥ 6.5%, fasting glucose ≥ 126 mg/dL (≥6.99 mmol/L), or history of diabetes* (N = 491)
1,5-Anhydroglucitol	0.66 (0.63 to 0.70)	0.59 (0.54 to 0.64)	0.58 (0.52 to 0.64)
Fructosamine	0.80 (0.76 to 0.83)	0.73 (0.69 to 0.78)	0.72 (0.67 to 0.78)
Glycated Albumin	0.82 (0.79 to 0.85)	0.75 (0.70 to 0.80)	0.74 (0.68 to 0.79)

^*Self-reported history of diabetes or diabetes medication use.

^**AUC represents the area under the receiver operating characteristic curve. Confidence intervals were calculated using bias corrected bootstrapping with 1,000 replications.