TABLE 2.
Patient Characteristics
| Factor at first transplant | Overall no. with factor/no. with valid data for factor (%) | Treatment group: No. of patients/total no. (%)
|
P | ||
|---|---|---|---|---|---|
| Nonprotocol | Other protocol | TT protocols 1, 2, 3 | |||
| Women | 1157/3075 (38) | 334/894 (37) | 401/1103 (36) | 422/1078 (39) | .397 |
| White | 2744/3074 (89) | 787/894 (88) | 995/1102 (90) | 962/1078 (89) | .269 |
| Age ≥65 y | 689/3077 (22) | 248/895 (28) | 229/1104 (21) | 212/1078 (20) | <.001 |
| IgA subtype | 557/2634 (21) | 124/610 (20) | 194/971 (20) | 239/1053 (23) | .279 |
| K light chain | 1649/2555 (65) | 371/590 (63) | 632/942 (67) | 646/1023 (63) | .119 |
| Hemoglobin <10 g/dL | 942/2884 (33) | 322/829 (39) | 366/989 (37) | 254/1066 (24) | <.001 |
| Platelets <100,000/mL | 354/2884 (12) | 174/829 (21) | 102/989 (10) | 78/1066 (7) | <.001 |
| Creatinine ≥1.5 mg/dL | 414/2883 (14) | 175/829 (21) | 152/989 (15) | 87/1065 (8) | <.001 |
| Albumin <3.0 g/dL | 263/2881 (9) | 123/830 (15) | 110/986 (11) | 30/1065 (3) | <.001 |
| CRP ≥6.0 mg/L | 1091/2776 (39) | 333/800 (42) | 412/942 (44) | 346/1034 (33) | <.001 |
| B2M ≥3.0 mg/L | 986/2810 (35) | 345/799 (43) | 351/968 (36) | 290/1043 (28) | <.001 |
| LDH ≥190 U/L | 811/2877 (28) | 248/827 (30) | 259/986 (26) | 304/1064 (29) | .202 |
| Cytogenetic abnormality | 1085/3016 (36) | 337/863 (39) | 368/1078 (34) | 380/1075 (35) | .070 |
| CA13/hypodiploidy | 733/3016 (24) | 248/863 (29) | 239/1078 (22) | 246/1075 (23) | .001 |
| CR prior to first transplant | 335/2774 (12) | 62/795 (8) | 96/942 (10) | 177/1037 (17) | <.001 |
| First transplant within 6 mo of first therapy | 1939/3004 (65) | 581/852 (68) | 691/1099 (63) | 667/1053 (63) | .031 |
| Completed 2 transplants | 2178/3077 (71) | 504/895 (56) | 779/1104 (71) | 895/1078 (83) | <.001 |
| Time interval <6 mo to second transplant | 1858/2178 (85) | 407/504 (81) | 613/779 (79) | 838/895 (94) | <.001 |
| Post-transplantation CR | 1520/2967 (51) | 378/861 (44) | 489/1058 (46) | 653/1048 (62) | <.001 |
TT indicates Total Therapy; IgA, immunoglobulin A; CRP, C-reactive protein; B2M, β-2-microglobulin; LDH, lactate dehydrogenase; CA, cytogenetic abnormality; CR, complete response.