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. Author manuscript; available in PMC: 2014 Mar 15.
Published in final edited form as: J Immunol. 2013 Feb 8;190(6):2519–2526. doi: 10.4049/jimmunol.1202104

Figure 4. Anti-insulin B lymphocytes induce proliferation of BDC2.5/NOD T cells.

Figure 4

A) BDC2.5/NOD CD4+ T cell proliferative response to titrated concentrations of conjugate antigen and 125Tg/NOD B cells (black bars), 281Tg/NOD non-insulin binding control B cells (dark gray bars) or with antigen alone (light gray bars), by 3H-thymidine incorporation. B) Proliferative BDC2.5/NOD T cell responses in response to co-culture with antigen-pulsed B cells (as in figure 2). Bars indicate the average of triplicate samples, with error bars demarking standard deviations. *p<0.05, **p<0.01. Data are representative of more than 3 independent experiments, n=2–3 pooled mice per genotype per sample.