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Embryonic overexpression of let-7 miRNA reduces germ cell pool size. (A) let-7 levels of primordial germ cells in E13.5 embryos. N=3. (B) iLet-7 and control newborn testes and ovaries. (C) Number of Mvh+ germ cells per tubule in iLet-7 and control newborn testes. N=286–303 from 3 mice. (D) Number of Mvh+ germ cells per 1000 µm2 in iLet-7 and control ovaries. N=3–5. * p<0.05, ** p<0.01. Error bars represent SEM. Scale bars 100 µm.
