Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Illustrates the control ligand 2 incorporating the bioactive heterocycle (pink) into the peptide template. The amino acid substitutions at each of the R positions [R1=His (Green), R2=DPhe (Orange), R3=Arg (Blue), R4=Trp (Red) of the melanocortin ligand pharmacophore domain are indicated. The library design approach was based upon the positional scanning method where one R position is modified while holding the other positions constant.
