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. Author manuscript; available in PMC: 2014 Apr 11.
Published in final edited form as: J Med Chem. 2013 Mar 25;56(7):2747–2763. doi: 10.1021/jm301253y

Figure 6.

Figure 6

Histogram comparing the relative fold change in EC50 values of the indicated amino acid relative to the appropriate control ligand at the mMC1R. Color coding- the black bar represents the tetrapeptide template Ac-His-DPhe-Arg-Trp-NH2. The blue bar represents the KAR template Tyr-c[β-Asp-His-DPhe-Arg-Trp-Asn-Ala-Phe-Dpr]-Tyr-NH2. The red bar represents the control ligand 2 in this study. ‡ Signifies that this amino acid substitution was not reported in one of the templates used for the comparative analysis in this study. @ Indicates that the modification results in an increase in potency and is shown as bars pointing down.