Table 1.

Cancer gene mountains identified through unbiased approaches.

Altered gene	Tumors with specific gene alterations	References
ALK	Lung cancer, neuroblastoma	(16–21)
ARID1A	Ovarian clear cell carcinoma, endometrioid tumors	(7, 8)
ATRX	Pancreatic neuroendocrine tumors	(9)
DAXX	Pancreatic neuroendocrine tumors	(9)
DNMT3A	Acute myeloid leukemia	(14)
FOXL2	Ovarian granulosa cell tumors	(32)
IDH1	Gliomas, acute myeloid leukemia	(3–5)
IDH2	Gliomas, acute myeloid leukemia	(3–5)
MLL2	Medulloblastoma, non-Hodgkin lymphoma	(11, 12)
NOTCH1	Head and neck cancer, chronic lymphocytic leukemia	(33–35)
PBRM1	Clear cell renal cancer	(10)
PPP2R1A	Ovarian clear cell carcinoma, uterine carcinoma	(7, 36)
TMPRSS/ERG	Prostate cancer	(6)
WWTR1/CAMTA1	Epithelioid hemangioendothelioma	(2)