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Brg1-dependent transrepression. Ligand (C) activation of glucocorticoid receptor (GR) results in formation of a Brg1-dependent protein complex, which also contains NGFI-B and HDAC2. This scenario results in deacetylation of histone H4, block of polymerase II at the promoter, and inhibition of transcription initiation. Hsp = heat shock protein; POMC = pro-opiomelanocortin.
