Fig. 5.

Actogram showing telemetric registration for 80 days of the “running activity” of a representative control mouse and a Crx^−/− mouse. For the first 40 days, the animals were exposed to a 12L:12D light regime (lights on at 7 a.m.). For the following 20 days, the light regime was phase advanced with 4 h (lights on at 3 a.m. and of at 3 p.m.). This was followed by continuous light for 10 days (LL). Finally, the animals were kept in constant darkness for 10 days (DD).