Table 1.

Genome-wide association analysis results of the CDC/AAP CP classification traits (severe CP versus healthy and moderate CP versus healthy) among the European American participants of the Dental ARIC study cohort (n = 4504), including single nucleotide polymorphisms (SNPs) with MAF-HapMap II CEU ≥ 5% and associated P < 5 × 10⁻⁶; the SNP with the lowest P-value per locus is presented; additional prioritized SNPs in each locus are presented in the footnote, along with corresponding r² (based on 1000 genomes pilot 1 release) with the top SNPs

Locus	SNP	Position Build36	Strand	Imputed	Major allele	MAFa (HapMap II-CEU)	Closest gene(s) and position or distance	Pb	Risk allele frequency disease/healthy	OR (95% CI)
Severe CP
14q21c	rs12883458	50349129	+	Yes	T	[C] 0.10	NIN (Intronic)	3.5 × 10−7	[C] 0.13/0.09	1.89 (1.48, 2.41)
7p15d	rs2521634	24344565	+	Yes	G	[A] 0.25	NPY (47Kb)	1.6 × 10−6	[G] 0.80/0.74	1.47 (1.25, 1.73)
3p21e	rs11925054	55365926	+	No	G	[T] 0.14	WNT5A (109Kb); ERC2 (151Kb)	6.5 × 10−7	[G] 0.90/0.86	1.69 (1.37, 2.10)
Moderate CP
6p21.1f	rs7762544	41487293	+	Yes	A	[G] 0.18	NCR2 (61Kb)	1.1 × 10−7	[G] 0.21/0.16	1.41 (1.24, 1.60)
19p13.3g	rs3826782	6838736	+	Yes	G	[A] 0.07	EMR1 (Intronic); VAV1 (30Kb)	4.0 × 10−6	[A] 0.05/0.04	2.00 (1.48, 2.70)
10p15	rs12260727	10378335	+	Yes	G	[A] 0.15	CELF2 (709Kb)	6.0 × 10−7	[G] 0.89/0.85	1.54 (1.30, 1.82)

CI, confidence interval.

^aMinor allele frequency.

^bBased on logistic regression, log-additive models, including terms for age, sex, study center and ancestry (10 first PCs).

^cAdditional SNPs in locus with P < 5 × 10⁻⁶: rs1004832 (r² = 1.00), rs8009874 (r² = 0.84) and rs12893300 (r² = 0.49).

^dAdditional SNP in locus with P < 5 × 10⁻⁶: rs11771124 (r² = 1.00).

^eAdditional SNP in locus with P < 5 × 10⁻⁶: rs503022 (r² = 0.52).

^fAdditional SNPs in locus with P < 5 × 10⁻⁶: rs9357360 (r² = 0.89), rs1853406 (r² = 0.89) and rs1535582 (r² = 0.33).

^gAdditional SNP in locus with P < 5 × 10⁻⁶: rs12610529 (r² = 0.79).