Table 3.
Volunteer ratings on questionnaires completed approximately 7 h after drug administration1
| Placebo | 0.25 TRZ | 0.5 TRZ | 100 DXM | 200 DXM | 300 DXM | Penultimate DXM | Maximum DXM | |
|---|---|---|---|---|---|---|---|---|
| Like the Experience? | ||||||||
| Rating (0 to 4) | 1.25 (0.28) | 1.67 (0.28) | 1.25 (0.22) | 1.33 (0.33) | 1.67 (0.48) | 1.75 (0.28) | 2.58 (0.38) | 2.83 (0.37) |
| Hallucinogen Rating Scale (HRS) 2 | ||||||||
| Intensity | 0.31 (0.16) | 0.98 (0.28) | 1.42 (0.14) | 1.40 (0.25) | 1.77 (0.25) | 2.15 (0.26) | 2.44 (0.17) | 3.08 (0.14) |
| Somaesthesia | 0.26 (0.07) | 0.21 (0.07) | 0.28 (0.04) | 0.60 (0.12) | 1.10 (0.23) | 1.22 (0.17) | 1.54 (0.20) | 1.87 (0.23) |
| Affect | 0.53 (0.08) | 0.41 (0.08) | 0.34 (0.05) | 0.69 (0.14) | 0.85 (0.17) | 0.95 (0.13) | 1.35 (0.23) | 1.91 (0.25) |
| Perception | 0.20 (0.08) | 0.22 (0.08) | 0.21 (0.07) | 0.53 (0.17) | 0.55 (0.15) | 1.03 (0.17) | 1.57 (0.23) | 1.94 (0.35) |
| Cognition | 0.27 (0.08) | 0.24 (0.11) | 0.32 (0.08) | 0.43 (0.13) | 0.75 (0.17) | 1.11 (0.16) | 1.73 (0.25) | 2.11 (0.33) |
| Volition | 1.01 (0.10) | 1.14 (0.20) | 1.43 (0.22) | 1.08 (0.13) | 1.21 (0.11) | 1.44 (0.10) | 1.55 (0.10) | 2.01 (0.18) |
| Mysticism Scale 3 | ||||||||
| Interpretation | 32.3 (6.5) | 25.2 (4.7) | 22.2 (4.8) | 33.9 (5.8) | 47.4 (9.6) | 63.0 (7.7) | 78.5 (7.4) | 84.8 (6.7) |
| Introvertive | 22.1 (4.9) | 24.3 (3.6) | 23.4 (5.0) | 39.6 (6.5) | 40.6 (8.5) | 66.7 (8.2) | 77.8 (8.0) | 95.3 (3.9) |
| Extrovertive | 16.4 (4.0) | 15.0 (3.7) | 13.3 (3.4) | 20.5 (4.7) | 31.3 (6.6) | 34.2 (5.9) | 47.1 (6.3) | 50.7 (6.3) |
| Total (max score = 288) | 70.8 (14.1) | 64.5 (11.1) | 58.8 (12.8) | 94.0 (15.8) | 119.3 (24.2) | 163.8 (19.8) | 203.4 (19.5) | 230.8 (15.7) |
| States of Consciousness Questionnaire 4 | ||||||||
| Internal Unity | 1.0 (1.0) | 2.4 (2.1) | 0 (0) | 3.7 (2.1) | 7.0 (4.6) | 25.7 (8.9) | 43.3 (7.8) | 63.6 (9.8) |
| External Unity | 4.7 (3.0) | 5.5 (3.5) | 0.9 (0.7) | 5.0 (3.2) | 6.7 (4.6) | 17.7 (7.0) | 33.9 (7.4) | 48.8 (10.4) |
| Sense of Sacredness | 3.7 (2.4) | 3.6 (2.1) | 0.3 (0.3) | 7.1 (3.4) | 11.7 (6.7) | 29.7 (10.3) | 48.4 (10.0) | 61.8 (11.1) |
| Intuitive knowledge | 1 (0.7) | 0.5 (0.5) | 0.5 (0.5) | 3.5 (2.5) | 13.0 (5.9) | 20.0 (6.1) | 50.9 (9.0) | 66.4 (9.6) |
| Transcendence time/space | 1.3 (1.0) | 3.9 (1.2) | 6.1 (1.4) | 14.5 (6.3) | 8.5 (3.4) | 33.3 (8.0) | 48.9 (8.1) | 68.9 (8.9) |
| Deeply-felt positive mood | 10.6 (4.0) | 13.8 (3.1) | 8.8 (1.7) | 14.9 (4.7) | 18.6 (8.2) | 35.1 (9.0) | 52.0 (8.4) | 59.0 (8.9) |
| Ineffability | 4.4 (2.4) | 7.6 (4.1) | 0.7 (0.7) | 12.8 (4.0) | 14.4 (4.5) | 30.4 (8.4) | 53.1 (10.1) | 69.5 (7.1) |
| Total | 4.4 (1.9) | 6.1 (2.0) | 3.3 (0.6) | 10.4 (3.7) | 12.1 (5.1) | 30.1 (8.0) | 49.1 (8.1) | 64.6 (8.8) |
1
Data are means with 1 SEM shown in parenthesis (N=12 for Mysticism Scale, Hallucinogen Rating Scale, and Like the Experience rating; N=11 for States of Consciousness Questionnaire). Bold font indicates significant differences from placebo, (Fisher’s LSD p≤.0.05); TRZ (triazolam); DXM (dextromethorphan); see text for details of statistical analyses.
2
Maximum scores were 4.25 for Intensity and 4.0 for the other subscales.
3
Maximum possible scores were 108, 108, 72, and 288 for Interpretation, Introvertive, Extrovertive, and Total, respectively.
4
Data are expressed as a percentage of maximum possible score.